Multi-scale dynamical modelling of T-cell development from an early thymic progenitor state to lineage commitment.Victor Olariu, MaryA. Yui, Pawel Krupinski, Wen Zhou, Julia Deichmann, Emil Andersson, Ellen V. Rothenberg, Carsten Peterson. Cell Reports. 2021; 34(2):108622

https://doi.org/10.1016/j.celrep.2020.108622

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A Quantitative Model of Cellular Decision Making in Direct Neuronal Reprogramming.

Adriaan Merlevede, Viktor Drugge, Roger A. Barker, Janelle Drouin-Ouellet, Victor Olariu. Sci. Rep. 2021; 11, 1514 https://doi.org/10.1038/s41598-021-81089-8

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Kinetic models of hematopoietic differentiation

Victor Olariu, Carsten Peterson, Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 2018; 11(1): e1424

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A deterministic method for estimating free energy genetic network landscapes with applications to cell commitment and reprogramming paths.

 Victor Olariu, Manesso Erica, Carsten Peterson, Royal Society Open Science.

2017;4(6):160765. doi:10.1098/rsos.160765

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Different reprogramming propensities in plants and mammals: Are small variations in the core network wirings responsible?

Victor Olariu, Julia Nilsson, Henrik Jönsson, Carsten Peterson, PLoS One. 2017 Apr 6;12(4):e0175251. doi: 10.1371/journal.pone.0175251.

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Nanog, Oct4 and Tet1 interplay in establishing pluripotency.

Victor Olariu, Cecilia Lövkvist, Kim Sneppen, Nature Scientific Reports, 2016; 6:25438 doi:10.1038/srep25438

 

A somatic mutation of GFI1B identified in leukemia alters cell fate via a SPI1 (PU.1) centered genetic regulatory network.

 Eduardo Anguita, Rajeev Gupta, Victor Olariu, Peter J. Valk, Carsten Peterson, Ruud Delwel, Tariq Enver, Developmental Biology, 2016, 411(2):277-286.

doi.org/10.1016/j.ydbio.2016.02.002

 

Stem Cells Dynamics - Naive Pluripotency and

Reprogramming

Victor Olariu, Open Access Biology London, 2014, 1(1):4 

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Dynamic analysis of gene expression and genome-wide transcription factor binding during lineage-specific differentiation of multipotent progenitors.

 Gillian May, Shamit Soneji, Alex J. Tipping, Jose Teles, Simon McGowan, Mengchu Wu, Yanping Guo, Cristina Fugazza, John Brown, Cristina Pina, Victor Olariu, Steve Taylor, Daniel G. Tenen, Carsten Peterson, Tariq Enver, Cell Stem Cell, 2013, 13:6:754-768 doi: 10.1016/j.stem.2013.09.003

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Probing the role of stochasticity in a model of the embryonic stem cell - heterogeneous gene expression and reprogramming efficiency.

 Vijay Chickarmane, Victor Olariu and Carsten Peterson, BMC Systems Biology, 2012, 6:98 doi:10.1186/1752-0509-6-98

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Prepatterning in the Stem Cell Compartment

 Peter D. Tonge, Victor Olariu, Daniel Coca, Visakan Kadirkamanathan, Kelly E. Burrell, Stephen A. Billings, Peter W. Andrews PLoS ONE, 2010, 5(5): e10901. doi:10.1371/journal.pone.0010901

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Modeling the evolution of culture-adapted human embryonic stem cells.

 Victor Olariu, S. Neil J. Harrison, Daniel Coca, Paul J. Gokhale, Duncan Baker, Steve Billings, Visakan Kadirkamanathan, Peter W. Andrews, Stem Cell Research, 2010, 4(1): 50-56 doi: 10.1016/j.scr.2009.09.001

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Modeling Stem Cells Lineages with Markov Trees

 Victor Olariu, Daniel Coca, Stephen A. Billings and Visakan Kadirkamanathan, Pattern Recognition in Bioinformatics Lecture Notes in Computer Science, 5780, 2009, 233-243

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Modified variational Bayes EM estimation of hidden Markov tree model of cell lineages.

Victor Olariu, Daniel Coca, Stephen A. Billings, Peter Tonge, Paul Gokhale, Peter W. Andrews and Visakan Kadirkamanathan, Bioinformatics, 2009, 25 (21): 2824-2830 doi: 10.1093/bioinformatics/btp456.